Organophosphate effects on antioxidant system of carp (Cyprinus carpio) and catfish (Ictalurus nebulosus)

The effect of the organophosphate insecticide Dichlorvos on antioxidant enzymes and other oxidative and redox parameters of carp (Cyprinus carpio L.) and catfish (Ictalurus nebulosus) were studied. Changes in superoxide dismutase, catalase, glutathione peroxidase, and in the case of carp acetylcholinesterase activities were studied in tissue homogenates. Other parameters studied: changes of lipid peroxidation, reduced glutathione and the amounts of two radicals, superoxide and hydroxyl radicals are compared. Our results showed that the organophosphate tested, besides its inhibitory effect on acetylcholinesterase--or together with it--induces changes characteristic of "oxidative stress."