Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Monocyte-macrophage function in the newborn

W L Weston, B S Carson, R M Barkin

    American Journal of Diseases of Children (1960)
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neurological grading, survival, MR imaging, and histological evaluation in the rat brainstem glioma model.

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2008
    Same author

    Ototoxicity of carboplatin delivered locally in a monkey brainstem.

    International journal of toxicology·2006
    Same author

    Toxicity and cerebrospinal fluid levels of carboplatin chronically infused into the brainstem of a primate.

    Journal of neuro-oncology·2004
    Same author

    Hemispherectomy for intractable unihemispheric epilepsy etiology vs outcome.

    Neurology·2003
    Same author

    Allergic contact dermatitis in children: a practical approach to management.

    Skin therapy letter·2003
    Same author

    The postoperative course and management of 106 hemidecortications.

    Pediatric neurosurgery·2002
    Same journal

    Nonsteroidal anti-inflammatory drugs and gastrointestinal injury in children.

    American journal of diseases of children (1960)·1993
    Same journal

    Picture of the month. Cutaneous leishmaniasis.

    American journal of diseases of children (1960)·1993
    Same journal

    Pathological case of the month. Wells' syndrome.

    American journal of diseases of children (1960)·1993
    Same journal

    Radiological case of the month. Proteus syndrome: benign angiolipomatous tumor with intraspinal extension.

    American journal of diseases of children (1960)·1993
    Same journal

    Applicability of the Greulich and Pyle skeletal age standards to black and white children of today.

    American journal of diseases of children (1960)·1993
    Same journal

    Maltreatment of children born to cocaine-dependent mothers.

    American journal of diseases of children (1960)·1993
    See all related articles

    Neonatal monocytes show a specific defect in cellular chemotaxis, impacting their ability to move towards infection sites. This immune system vulnerability may explain why newborns are more susceptible to certain infections.

    Area of Science:

    • Immunology
    • Neonatal Biology
    • Cellular Biology

    Background:

    • Neonates exhibit increased susceptibility to infections.
    • Monocyte-macrophage function plays a critical role in host defense.
    • Understanding neonatal immune system defects is crucial for improving infant health outcomes.

    Purpose of the Study:

    • To investigate monocyte-macrophage function in human cord blood samples.
    • To identify specific immune defects in neonatal monocytes.
    • To correlate these defects with increased neonatal susceptibility to infections.

    Main Methods:

    • Analysis of 20 human cord blood samples.
    • Comparative study with 30 healthy young adult controls.
    • Assays for monocyte bacterial phagocytosis, particle phagocytosis, bacterial killing, and cellular chemotaxis.

    Related Experiment Videos

    Main Results:

    • A selective defect in monocyte cellular chemotaxis was observed in cord blood samples.
    • Monocyte bacterial phagocytosis, particle phagocytosis, and bacterial killing functions were normal.
    • Neonatal monocytes demonstrated an impaired response to chemotactants.

    Conclusions:

    • Neonatal monocytes possess a specific defect in cellular chemotaxis.
    • This chemotactic defect is an additional host defense vulnerability in neonates.
    • The impaired chemotaxis may contribute to the heightened susceptibility of neonates to specific infectious agents.