[The tubulointerstitial changes in different clinical and morphological types of chronic glomerulonephritis]

As shown by the data available on 228 patients with chronic glomerulonephritis, tubulointerstitial alterations (TIA) occur primarily in mesangiocapillary glomerulonephritis, focal-segmental glomerular hyalinosis/sclerosis, diffuse fibroplastic glomerulonephritis as well as in active nephritic and nephrotic-hypertensive types. In 186 patients with chronic glomerulonephritis chronic renal insufficiency evidencing enhanced progression (EP) if arose within 7 years since the disease onset in the presence of TIA was registered significantly more frequently. TIA patients demonstrated EP as a rule in prognostically unfavorable active nephritic and nephrotic-hypertensive types. The relationship between TIA and EP may be explained by their association with unfavourable clinical types suggesting poor prognosis.