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Randomized controlled trial of superovulation and insemination for infertility associated with minimal or mild
I S Tummon1, L J Asher, J S Martin
1University of Western Ontario, London, Canada.
Objective:
To evaluate the efficacy of superovulation and IUI versus no treatment for infertility associated with minimal or mild endometriosis.
Design:
Randomized trial.
Setting(S):
London Health Sciences Centre, University Campus, The University of Western Ontario, London, Ontario; and Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
Patient(S):
Three hundred eleven cycles in 103 couples in whom minimal or mild endometriosis was the sole identified subfertility factor.
Intervention(S):
Superovulation with FSH and IUI.
Main Outcome Measure(S):
Live birth.
Result(S):
Live birth followed 14 of 127 (11%) superovulation and IUI cycles and 4 of 184 (2%) no-treatment cycles. The odds ratio was 5.6 (95% confidence interval 1.8 to 17.4) in favor of superovulation and IUI.
Conclusion(S):
Treatment with superovulation and IUI was associated with superior outcome both by crude live-birth rates and proportional hazard analysis.
