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Related Experiment Videos

Persisting childish behavior after bilateral thalamic infarcts

R Fukatsu1, T Fujii, A Yamadori

  • 1Department of Neurology, Miyagi National Hospital, Japan.

European Neurology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Bilateral paramedian thalamic infarcts caused significant personality changes, including childish behavior and euphoria, along with memory deficits. These neurological deficits persisted for two years, highlighting the thalamus

Area of Science:

  • Neurology
  • Neuroscience
  • Neuroimaging

Background:

  • Thalamic lesions are associated with various cognitive and behavioral deficits.
  • Understanding the specific functional roles of thalamic subregions is crucial for interpreting neurological symptoms.
  • Bilateral paramedian thalamic infarcts are rare and their precise clinical manifestations require detailed investigation.

Observation:

  • A patient presented with bilateral paramedian thalamic infarcts following a stroke.
  • The patient exhibited profound personality changes, including childish behavior and euphoria, persisting for two years.
  • Additional symptoms included 'Vorbeireden' (approximate answers), anterograde and retrograde amnesia, and vertical gaze palsy.

Findings:

  • Magnetic Resonance Imaging (MRI) confirmed bilateral medial thalamic and right midbrain infarcts.

Related Experiment Videos

  • Positron Emission Tomography (PET) revealed markedly decreased cerebral metabolic rate for glucose (CMRglc) in both thalami and cerebellum.
  • Slightly decreased CMRglc was noted in parietal and occipital regions, with normal frontal and temporal CMRglc.

    • Implications:

    • The study suggests that paramedian thalamic lesions are strongly implicated in the observed personality changes, 'Vorbeireden', and amnesia.
    • This case underscores the critical role of the paramedian thalamus in regulating personality, memory, and executive functions.
    • Findings contribute to a better understanding of the neuroanatomical basis of complex behavioral and cognitive disorders following stroke.