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Dopamine, the prefrontal cortex and schizophrenia

M B Knable1, D R Weinberger

  • 1National Institute of Mental Health, Intramural Research Program, Clinical Brain Disorders Branch, Washington, DC 20032, USA. knablem@dirpc.nimh.nih.gov

Journal of Psychopharmacology (Oxford, England)
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Schizophrenia may involve prefrontal cortex (PFC) dysfunction due to abnormalities in the mesocortical dopamine system. This review examines the dopamine system

Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Prefrontal cortex (PFC) dysfunction is implicated in schizophrenia.
  • The PFC has dense dopaminergic innervation, suggesting a role for the mesocortical dopamine system.

Purpose of the Study:

  • To review the anatomy, physiology, and pharmacology of the mesencephalic-frontal cortical dopamine system in relation to schizophrenia.
  • To present evidence for altered dopaminergic neurotransmission in the frontal cortex of schizophrenic patients.

Main Methods:

  • Literature review of anatomical, physiological, and pharmacological studies.
  • Synthesis of evidence from clinical, neuropsychological, and neuroimaging research.

Main Results:

  • The mesocortical dopamine system's role in schizophrenia pathophysiology is explored.

Related Experiment Videos

  • Evidence suggests altered dopaminergic neurotransmission in the schizophrenic frontal cortex.

    • Conclusions:

    • Dysfunction in the mesocortical dopamine system is a potential contributor to schizophrenia.
    • Further research into dopaminergic abnormalities in the PFC is warranted for understanding schizophrenia.