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Related Experiment Videos

Batch lot variability in permeation through nitrile gloves

J L Perkins1, B Pool

  • 1University of Alabama at Birmingham, School of Public Health 35294-0008, USA.

American Industrial Hygiene Association Journal
|July 1, 1997
PubMed
Summary

Chemical protective clothing selection relies on manufacturer data lacking variability insights. This study found significant batch-to-batch variations in nitrile glove permeation, suggesting quality control issues, not cure factors, are the primary cause.

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Area of Science:

  • Occupational Health and Safety
  • Materials Science
  • Chemical Engineering

Background:

  • Selection of chemical protective clothing often relies on manufacturers' permeation data.
  • This data typically lacks information on variability, presenting a challenge for accurate risk assessment.
  • Variability in performance may stem from manufacturing processes, such as cure factors.

Purpose of the Study:

  • To investigate batch-to-batch variability in chemical protective nitrile gloves.
  • To determine if glass transition temperature (Tg) correlates with permeation parameters and indicates cure variability.
  • To identify the primary sources of variability in glove permeation data.

Main Methods:

  • Measured steady state permeation rate, breakthrough detection time (BDT), and cumulative permeation (ASTM F1407) for two types of nitrile gloves across multiple batches.

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  • Determined glass transition temperature (Tg) (ASTM E1356) as an indicator of cure.
  • Analyzed statistical significance of batch-to-batch variability and correlation between Tg and permeation parameters.

    • Main Results:

    • Statistically significant batch-to-batch variability was observed for permeation rate, cumulative permeation, and Tg, but not for BDT.
    • Glass transition temperature (Tg) did not show a significant relationship with any of the measured permeation parameters.
    • While some variability may be method-related (per ASTM round-robin), manufacturer quality control is indicated as the major source of inconsistency.

    Conclusions:

    • Batch-to-batch variability in nitrile glove permeation is significant and not explained by cure factors indicated by Tg.
    • Manufacturer quality control processes are the likely primary cause of performance variability in chemical protective gloves.
    • Improved quality control measures are essential for reliable selection and use of chemical protective clothing.