Related Experiment Video
Updated: Aug 11, 2026

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
Published on: August 11, 2018
[Seven-year follow-up in pupils immunized with hepatitis B vaccine and its revaccination]
Abstract:
In order to evaluate immune persistence of plasma-derived hepatitis B vaccine (HBV), 344 children in a primary school were followed up for seven years by detection of serum HBsAg, anti-HBc and anti-HBs with radioimmunoassay (RIA) using Abbott reagent kits. In the seventh year after three-dose HBV immunization, level of anti-HBs in 55.4%-75.0% of the vaccinee was greater than 10 IU/L, with a geometric mean titer (GMT) of 20.9-65.3 IU/L. The higher the level of anti-HBs, the longer the duration of its decrease from more than to less than 10 IU/L. Seven years after immunization, 66 children with varied serum levels of anti-HBs were received a fourth dose of 10 micrograms HBV, and one month after revaccination, their levels of anti-HBs increased by 6.3-57.7 times. It suggests revaccination of HBV is not necessary for children vaccinated within seven years.
More Related Videos
Related Concept Videos
Vaccinations
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Vaccines
Smallpox
Chickenpox
Hepatitis

