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Related Experiment Videos

Small arterial reconstruction using modified cadaveric saphenous veins

A G Sheil, M S Stephen, J Boulas

    American Journal of Surgery
    |November 1, 1977
    PubMed
    Summary

    Modified human saphenous veins show promise as arterial substitutes. These modified vein allografts were successfully used in bypass surgeries, demonstrating potential for treating peripheral arterial disease.

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    Area of Science:

    • Vascular Surgery
    • Biomaterials Science
    • Regenerative Medicine

    Background:

    • Small arterial substitutes are crucial for revascularization.
    • Saphenous vein allografts are a potential option but require modification.
    • Previous unmodified allografts have shown limitations.

    Purpose of the Study:

    • To evaluate the efficacy of modified human saphenous vein allografts as small arterial substitutes.
    • To assess the long-term patency and complications of these modified grafts in canine and human subjects.

    Main Methods:

    • Human saphenous veins underwent proteolytic enzymatic digestion, cross bonding, and heparin bonding.
    • Modified veins were tested as arterial substitutes in canine models.
    • Modified veins were used as arterial bypasses in human patients with ischemic limbs.

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    Main Results:

    • Eight of eleven canine arterial substitutes were successful, with the longest patency of 18 months.
    • Nine of eleven human patients with no prior surgery on the target artery had successful bypasses, with healed limbs and functioning grafts between 3-12 months.
    • Three patients with prior surgery on the target artery experienced bypass failure, though amputation was avoided in one case.

    Conclusions:

    • Modified saphenous vein allografts are suitable for use as small arterial substitutes.
    • Further long-term studies are needed to confirm sustained patency and absence of complications.