Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of alpha-interferons on immune function

R B Herberman1

  • 1University of Pittsburgh Cancer Institute, Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA.

Seminars in Oncology
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor immunology.

JAMA·1992
Same author

The T-cell receptor V beta gene usage in tumor-infiltrating lymphocytes and blood of patients with hepatocellular carcinoma.

Cancer research·1992
Same author

Receptors for interleukin 2 on human squamous cell carcinoma cell lines and tumor in situ.

Cancer research·1992
Same author

Nongranular proteolytic enzymes of rat IL-2-activated natural killer cells. I. Subcellular localization and functional role.

Journal of immunology (Baltimore, Md. : 1950)·1992
Same author

Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells.

International journal of cancer·1992
Same author

Tissue distribution of adoptively transferred adherent LAK cells: role of the route of administration.

Natural immunity·1992
Same journal

A systematic scoping review of cancer-related anemia treatment: Comparative trial outcomes, current guidelines, and future perspectives.

Seminars in oncology·2026
Same journal

Steroid-induced tumor lysis syndrome in solid tumors: A case report and review of the literature.

Seminars in oncology·2026
Same journal

PSMA PET/CT staging in intermediate-risk prostate cancer: Toward risk-adapted implementation.

Seminars in oncology·2026
Same journal

Angiogenesis and the corresponding antiangiogenic therapy in gastroenteropancreatic neuroendocrine neoplasms.

Seminars in oncology·2026
Same journal

Post-translational regulation of steroidogenesis and its clinical relevance in hormone responsive cancers.

Seminars in oncology·2026
Same journal

Physics-informed machine learning for tumor microenvironment-responsive nanomedicine: Recent updates.

Seminars in oncology·2026
See all related articles

Alpha-interferons (IFN-alphas) modulate the immune system, notably enhancing natural killer cell activity through complex mechanisms. Variations in IFN-alphas impact this activity, suggesting a role in therapeutic efficacy.

Area of Science:

  • Immunology
  • Virology
  • Pharmacology

Background:

  • Alpha-interferons (IFN-alphas) exhibit diverse effects on immune cells.
  • A key observed effect is the augmentation of natural killer (NK) cell activity.
  • The mechanisms underlying IFN-alpha-mediated NK cell activation are intricate.

Purpose of the Study:

  • To review the immunomodulatory effects of IFN-alphas, focusing on NK cell activity.
  • To discuss variations in NK cell activation by different IFN-alpha types.
  • To explore the potential therapeutic implications of these immunomodulatory properties.

Main Methods:

  • Literature review and analysis of existing data on IFN-alphas and immune responses.
  • Comparison of NK cell stimulatory capacity across naturally occurring, recombinant, and consensus IFN-alphas.

Related Experiment Videos

  • Evaluation of experimental designs and their limitations in current research.

    • Main Results:

    • Significant variability (up to 100-fold) exists in the NK cell activating potential of different IFN-alphas.
    • Consensus IFN shows potential for high NK cell stimulation relative to antiviral activity, but definitive conclusions are lacking.
    • The complex immunomodulatory actions of IFN-alphas are evident.

    Conclusions:

    • IFN-alphas possess broad immunomodulatory effects impacting various immune components.
    • NK cell activity augmentation is a prominent, mechanistically complex effect of IFN-alphas.
    • The observed immunomodulatory effects likely contribute to the therapeutic benefits of IFN-alphas.