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Mucocutaneous paraneoplastic syndromes

P R Cohen1, R Kurzrock

  • 1Department of Dermatology, The University of Texas-Houston Medical School, 77030, USA.

Seminars in Oncology
|June 1, 1997
PubMed
Summary

Mucocutaneous paraneoplastic syndromes are skin conditions linked to internal cancers. Recognizing these dermatoses aids in early cancer detection or recurrence monitoring.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Mucocutaneous paraneoplastic syndromes are diverse skin conditions.
  • They can be idiopathic or associated with visceral malignancies.
  • These syndromes manifest with various dermatologic changes.

Purpose of the Study:

  • To review clinical characteristics of mucocutaneous paraneoplastic syndromes.
  • To summarize associated malignancies.
  • To outline diagnostic workups for associated cancers.

Main Methods:

  • Review of clinical characteristics.
  • Pathologic findings.
  • Associated malignancy data.

Main Results:

  • Syndromes categorized by predominant pathologic change (e.g., neutrophilic dermatoses, vasculitis).
  • Some syndromes correlate with hematologic malignancies, others with solid tumors.
  • Dermatosis can precede, coincide with, or follow cancer detection.

Conclusions:

  • Diagnosis of dermatosis confirmed by clinical and/or biopsy findings.
  • Establishes need for cancer evaluation or recurrence investigation.
  • Highlights the role of dermatologists in early cancer diagnosis.

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