Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

p53-induced p21 controls DNA replication

S Waga1, R Li, B Stillman

  • 1Cold Spring Harbor Laboratory, New York 11724, USA.

Leukemia
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution of DNA replication origin specification and gene silencing mechanisms.

Nature communications·2020
Same author

Point prevalence survey for tick-borne pathogens in military working dogs, shelter animals, and pet populations in northern Colombia.

Journal of special operations medicine : a peer reviewed journal for SOF medical professionals·2014
Same author

Computer-based video analysis of movement.

The Australian journal of physiotherapy·2014
Same author

Perceptions of the clinical efficacy of laser therapy.

The Australian journal of physiotherapy·2014
Same author

DNA replication. Genomic views of genome duplication.

Science (New York, N.Y.)·2001
Same author

The experience of back pain in young Australians.

Manual therapy·2001
Same journal

Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia.

Leukemia·2026
Same journal

Selective targeting of RSK signaling with PMD-026 suppresses FLT3-activated acute myeloid leukemia while sparing normal hematopoiesis.

Leukemia·2026
Same journal

FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia.

Leukemia·2026
Same journal

Spatial remodeling of bone marrow architecture defines tissue-state signatures of disease activity and therapeutic response in myelodysplastic neoplasms.

Leukemia·2026
Same journal

Selective sensitivity of Ph-like B-cell acute lymphoblastic leukemia to BRG1 inhibition identifies a therapeutic vulnerability.

Leukemia·2026
Same journal

Unpacking the epigenetic landscape of acute lymphoblastic leukemia: resolving cellular heterogeneity and nutritional complexities.

Leukemia·2026
See all related articles

The p21 protein interacts with proliferating cell nuclear antigen (PCNA) to maintain genome integrity. This interaction is crucial for cell cycle regulation and DNA repair in normal cells, but often disrupted in tumors.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • The p21 protein is a key regulator of cyclin-dependent kinases (CDKs) involved in cell proliferation suppression after DNA damage.
  • In normal cells, p21 forms a complex with cyclin, CDK, and proliferating cell nuclear antigen (PCNA), a DNA replication and repair factor.
  • This quaternary complex is suggested to be vital for maintaining genome integrity.

Purpose of the Study:

  • To investigate the interaction between p21 and PCNA.
  • To elucidate the role of the p21-PCNA complex in DNA replication and repair.

Main Methods:

  • In vitro studies of p21-PCNA interaction.
  • In vivo studies of p21 function in the context of DNA replication and repair.

Related Experiment Videos

Main Results:

  • Data presented from both in vitro and in vivo experiments.
  • Focus on the functional significance of the p21-PCNA interaction.

Conclusions:

  • The p21-PCNA interaction is a critical mechanism for genome maintenance.
  • Understanding this interaction may provide insights into cancer development and therapeutic strategies.