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Chloroquine induces basophilic differentiation of HL-60 cells
R Sasaki1, Y Furukawa, K Okada
1Division of Hematology, Jichi Medical School, Tochigi, Japan.
Leukemia
|April 1, 1997
Abstract:
Many agents have been known to induce the differentiation of HL-60 cells. However, only a small number of reports on the basophilic differentiation of this cell line are known. In this study we show that the exposure of HL-60 cells to chloroquine induces to differentiate into basophils. This chloroquine-induced change suggests that the increase in intracellular pH and the upregulation of p21 with subsequent downregulation of cdc2 kinase are triggers for basophilic differentiation of this cell line.