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Related Experiment Videos

Panic disorder with familial bipolar disorder

D F MacKinnon1, F J McMahon, S G Simpson

  • 1Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Biological Psychiatry
|July 15, 1997
PubMed
Summary

Comorbid panic disorder may indicate genetic subtypes of bipolar disorder. Families with bipolar disorder and panic disorder showed distinct patterns of other psychiatric conditions, suggesting genetic heterogeneity.

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Area of Science:

  • Psychiatry
  • Genetics
  • Clinical Psychology

Background:

  • Bipolar disorder is a complex psychiatric condition with suspected genetic underpinnings.
  • Genetic heterogeneity in bipolar disorder may manifest as distinct familial subtypes.
  • Investigating psychiatric comorbidities can help delineate these potential subtypes.

Purpose of the Study:

  • To explore whether panic disorder comorbidity in bipolar disorder is associated with specific familial patterns of other psychiatric disorders.
  • To test the hypothesis that panic disorder serves as a marker for genetic heterogeneity in bipolar disorder.

Main Methods:

  • A genetic linkage study involving 528 members from 57 families ascertained for bipolar disorder.
  • Families were categorized based on the presence of panic disorder in the bipolar proband.

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  • Prevalence rates of panic disorder and other psychiatric conditions were compared between relatives of probands with and without panic disorder.

    • Main Results:

    • Panic disorder was present in 88% of subjects with both panic and bipolar disorder.
    • Panic disorder was diagnosed in 18% of bipolar disorder family members.
    • Relatives of bipolar probands with panic disorder showed higher rates of panic disorder, bipolar II, cyclothymia, and dysthymia, but lower rates of substance abuse compared to relatives of probands without panic disorder.

    Conclusions:

    • Comorbid panic disorder in bipolar disorder may be a clinical marker for genetic heterogeneity.
    • These findings support the hypothesis that distinct familial subtypes of bipolar disorder exist.
    • Further research can investigate the specific genetic factors underlying these proposed subtypes.