Related Experiment Video
Updated: Oct 17, 2026

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
Published on: March 21, 2021
Air pollution and hospital admissions for respiratory causes in Minneapolis-St. Paul and Birmingham
S H Moolgavkar1, E G Luebeck, E L Anderson
1Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.
Abstract:
We investigated the association between air pollution and hospital admissions for chronic obstructive pulmonary disease and pneumonia among the elderly in Minneapolis-St. Paul, MN, and Birmingham, AL, over the period January 1, 1986, to December 31, 1991. Pollutants included in our analyses were PM10 (particulate matter less than 10 microns in aerodynamic diameter), SO2, NO2, O3, and CO in Minneapolis-St. Paul, and PM10, O3, and CO in Birmingham. After adjusting for temperature, day of week, season, and temporal trends, we found little evidence of association between air pollution and hospital admissions for respiratory causes in Birmingham. In contrast, we found that air pollution was associated with hospital admissions for respiratory causes in Minneapolis-St. Paul. Among the individual pollutants, O3 was most strongly associated with admissions (estimated increase in hospital admissions associated with a 15-parts-per-billion increase in O3 on the previous day = 5.15%; 95% confidence interval = 2.36-7.94%), and this association was robust in the sense that it was little affected by the simultaneous consideration of other pollutants. PM10, SO2, and NO2 were also associated with hospital admissions, although none could be singled out as being more important than the others.
Insights
Air pollution, particularly ozone (O3), is linked to increased hospital admissions for respiratory illnesses like COPD and pneumonia in elderly populations in Minneapolis-St. Paul. Birmingham showed no significant associations.
Area of Science:
- Environmental Health
- Epidemiology
- Pulmonary Medicine
Background:
- Elderly populations are vulnerable to the health impacts of air pollution.
- Chronic obstructive pulmonary disease (COPD) and pneumonia are significant respiratory diseases affecting the elderly.
Purpose of the Study:
- To investigate the association between specific air pollutants and hospital admissions for respiratory diseases in the elderly.
- To compare these associations in two distinct US metropolitan areas: Minneapolis-St. Paul, MN, and Birmingham, AL.
Main Methods:
- Ecological study design analyzing daily hospital admissions for respiratory causes against daily air pollution levels (PM10, SO2, NO2, O3, CO).
- Data collected from January 1, 1986, to December 31, 1991.
- Statistical models adjusted for temperature, day of week, season, and temporal trends.
Main Results:
- A significant association was found between air pollution and respiratory hospital admissions in Minneapolis-St. Paul, but not in Birmingham.
- Ozone (O3) showed the strongest association in Minneapolis-St. Paul, with a 5.15% increase in admissions per 15-ppb increase on the prior day.
- Particulate Matter (PM10), sulfur dioxide (SO2), and nitrogen dioxide (NO2) were also associated with admissions in Minneapolis-St. Paul.
Conclusions:
- Air pollution poses a risk for respiratory hospital admissions among the elderly in Minneapolis-St. Paul.
- Ozone is a key pollutant of concern for respiratory health in this population.
- Geographic variations in air pollution-respiratory illness associations exist.
More Related Videos
Related Concept Videos
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Asthma-I: Introduction
Asthma I: Introduction
Asthma III: Clinical Manifestations
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Pneumonia I: Introduction

