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Anti-HIV active naphthyl analogues of HEPT and DABO
K Danel1, C Nielsen, E B Pedersen
1Department of Chemistry, Odense University, Denmark.
Acta Chemica Scandinavica (Copenhagen, Denmark : 1989)
|March 1, 1997
Abstract:
5-Ethyl-6-(1-naphthylmethyl)uracil and 5-ethyl-6-(1-naphthylmethyl)-2-thiouracil were alkylated to give, respectively. N-1 and S2, ethoxymethyl and methylthiomethyl uracil derivatives. 5-Ethyl-6-(1-naphthylmethyl)-2-thiouracil was also S2 alkylated with methyl bromoacetate. The products showed activity against HIV-1, and the N-1 alkylated derivatives were indeed highly active.
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