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Purification of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids for clinical applications using
M W Brechbiel1, P M Beitzel, O A Gansow
1Radioimmune and Inorganic Chemistry Section, NCI, NIH, Bethesda, MD 20892-1002, USA.
Journal of Chromatography. A
|May 30, 1997
Abstract:
A general process for the purification of large quantities (5-10 g) of p-nitrobenzyl C-functionalized diethylenetriamine pentaacetic acids is reported. The method of choice to achieve purification for clinical applications is anion-exchange chromatography.