Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in baroreceptor vagal reflex performance in the developing rat

S Kasparov1, J F Paton

  • 1Department of Physiology, School of Medical Sciences, University of Bristol, Bristol, BS8 1TD, UK.

Pflugers Archiv : European Journal of Physiology
|August 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protective Effect of Memantine on Bergmann Glia and Purkinje Cells Morphology in Optogenetic Model of Neurodegeneration in Mice.

International journal of molecular sciences·2021
Same author

CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.

Neuropharmacology·2018
Same author

Hypothalamic paraventricular nucleus neuronal nitric oxide synthase activity is a major determinant of renal sympathetic discharge in conscious Wistar rats.

Experimental physiology·2017
Same author

A Role for Astrocytes in Sensing the Brain Microenvironment and Neuro-Metabolic Integration.

Neurochemical research·2015
Same author

Neck muscle afferents influence oromotor and cardiorespiratory brainstem neural circuits.

Brain structure & function·2014
Same author

Lactate-mediated glia-neuronal signalling in the mammalian brain.

Nature communications·2014
Same journal

Expression of protein kinase A catalytic subunits in healthy and diseased mouse kidneys.

Pflugers Archiv : European journal of physiology·2026
Same journal

Localization of O₂‑sensing ADO‑RGS pathway components in mouse and human kidneys under normoxia, hypoxia and renal fibrosis.

Pflugers Archiv : European journal of physiology·2026
Same journal

Cholesterol-depleting dextrin depolarizes sarcolemma: the contribution of sodium / calcium channels and membrane integrity.

Pflugers Archiv : European journal of physiology·2026
Same journal

Inhibition of (interstitial) P2Y<sub>6</sub> receptors attenuates fibrosis progression.

Pflugers Archiv : European journal of physiology·2026
Same journal

Renal NHE3 is required to limit hypokalemia and metabolic acidosis during dietary potassium deficiency.

Pflugers Archiv : European journal of physiology·2026
Same journal

Xenin-25 improves indomethacin-induced acute gastric injury in rats.

Pflugers Archiv : European journal of physiology·2026
See all related articles

The baroreceptor vagal reflex matures in rats, showing functional capacity early but attenuating during postnatal development (P10-P20). This occurs alongside a rise in blood pressure, indicating developmental changes in cardiovascular regulation.

Area of Science:

  • Physiology
  • Developmental Biology
  • Cardiovascular Science

Background:

  • Vagal control of heart rate and baroreceptor reflexes are crucial for cardiovascular homeostasis.
  • Understanding the ontogenesis of these reflexes is vital for comprehending normal physiological development and potential pathologies.

Purpose of the Study:

  • To investigate the developmental timeline of vagal control of heart rate and baroreceptor reflex sensitivity in rats.
  • To correlate changes in these reflexes with maturation of the cardiovascular system.

Main Methods:

  • Evaluation of heart rate and mean arterial pressure in rats at various postnatal ages (P5/6 to >42 days).
  • Assessment of cardiac vagal tone using atropine.
  • Measurement of baroreceptor cardiac reflex sensitivity via phenylephrine administration.

Related Experiment Videos

  • Testing central and peripheral efferent pathways using L-glutamate microinjections.

    • Main Results:

    • Heart rate and mean arterial pressure increased significantly from P5/6 to P25.
    • Cardiac vagal tone was absent at P10, becoming significant at P20.
    • Baroreceptor cardiac reflex sensitivity was attenuated in P10-20 rats compared to younger and mature animals.
    • Central and peripheral pathways of the baroreceptor reflex were functional in young rats.

    Conclusions:

    • The baroreceptor vagal reflex is functional at a very early postnatal age (P5/6).
    • A significant attenuation of this reflex occurs between P10-P20, coinciding with rising arterial pressure.
    • These findings highlight a critical developmental window for cardiovascular reflex maturation.