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[Macrophage enhancement of the immunogenicity of a suboptimal dosage of antigen-antibody complex]

N A Matienko, V I Kaledin, V P Nikolin

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |October 1, 1979
    PubMed

    Dawley mice were immunized with rabbit gamma globulin combined with allotypical antibodies, introduced alone or after preliminary incubation with syngeneic macrophages. Enhanced immune response was observed in the rats immunized both with low (0.11 mg) and high (1.1 mg) doses of the antigen with macrophages. A conclusion was made that this enhanced response had no connection with the elimination of the excess antigen by the macrophages.

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