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Related Concept Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow08:58

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This protocol provides a method for the systematic global optimization of genetically encoded biosensors through automation-assisted genetic library generation and assessment. This is coupled with design-of-experiment methodologies to streamline experimentation and enable the selection of genetic components to tune biosensors to specific design outcomes.
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Access to decentralized, low-cost, and high-capacity diagnostics that can be deployed into the community for decentralized testing is critical for combating global health crises. This manuscript describes how to build paper-based diagnostics for viral RNA sequences that can be detected with a portable optical...
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Field-effect biosensing (FEB) is a label-free technique for detecting biomolecular interactions. It measures the electric current through the graphene biosensor to which the binding targets are immobilized. The FEB technology was used to evaluate biomolecular interactions between Hsp90 and Cdc37 and a strong interaction between the two proteins was...
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This study aimed to present a strategy for identifying drug-peptide interactions. The strategy involves the biopanning of drug-recognizing short peptides based on a quartz-crystal microbalance (QCM) biosensor, followed by bioinformatics analysis for quantitatively assessing the information obtained for the drug recognition and annotation of the drug-binding sites on...
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The synthesis of asymmetric species of ferrocene is challenging using solution techniques. This report focuses on the methods carried out to produce a ferrocene-biotin bioconjugate using facile and clean reactions accomplished via solid-phase synthesis. Incorporation of a thiolate moiety is shown to impart the ability for immobilization on gold...
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Related Experiment Video

Updated: Jan 7, 2026

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

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Sinusitis: bench to bedside. Current findings, future directions

M A Kaliner1, J D Osguthorpe, P Fireman

  • 1Institute for Asthma and Allergy at Washington Hospital Center, Washington, D.C., USA.

The Journal of Allergy and Clinical Immunology
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Sinusitis, a common sinus inflammation, is increasing in the U.S., causing millions of restricted activity days. Research is needed to understand its causes, pathophysiology, and optimal treatments for better patient quality of life.

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Last Updated: Jan 7, 2026

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Area of Science:

  • Sinusitis research
  • Inflammatory disease epidemiology
  • Public health

Background:

  • Sinusitis affects 14% of the U.S. population, with rising prevalence.
  • Increased restricted activity days highlight the growing burden of sinusitis.
  • Unanswered questions regarding cause, pathophysiology, and treatment impact healthcare costs and quality of life.

Framework:

  • A collaborative meeting convened by AAAAI, AAO-HNS, and NIAID in January 1996.
  • Focused on identifying critical research directions for sinus disease.
  • Aimed to establish a foundation for future sinusitis investigations.

Implementation:

  • Summary of proceedings from the January 1996 meeting.
  • Provides background for future research on sinusitis.
  • Highlights key areas needing further scientific inquiry.

Implications:

  • Addresses the need for further research into sinusitis.
  • Aims to improve understanding and management of this common condition.
  • Contributes to reducing healthcare costs and improving patient quality of life.