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Related Experiment Videos

Acquired isolated factor VII deficiency during sepsis

C Biron1, C Bengler, J C Gris

  • 1Laboratory of Haematology, Saint Eloi University Hospital, Montpellier, France.

Haemostasis
|March 1, 1997
PubMed
Summary

Severe sepsis can cause acquired factor VII deficiency, mimicking a congenital condition. Factor VII levels normalize after sepsis recovery, highlighting a transient deficiency linked to severe infections.

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Isolated acquired factor VII deficiency is a rare clinical finding.
  • Severe systemic sepsis can present with complex hemostatic abnormalities.
  • Distinguishing acquired from congenital factor VII deficiency is crucial for appropriate patient management.

Purpose of the Study:

  • To investigate the association between severe systemic sepsis and acquired factor VII deficiency.
  • To characterize the clinical and laboratory findings in patients with sepsis-induced factor VII deficiency.
  • To differentiate this acquired condition from congenital factor VII deficiency.

Main Methods:

  • Retrospective analysis of 11 patients with acquired factor VII deficiency.
  • Assays included clotting tests and amidolytic assays for factor VII activity.

Related Experiment Videos

  • Measurement of factor VII antigen levels and other hemostasis markers (D-dimers, prothrombin fragments 1.2, thrombin-antithrombin complexes).

    • Main Results:

    • All 11 patients presented with heterozygous-like factor VII deficiency during severe sepsis.
    • Low factor VII antigen levels and elevated hemostasis markers were observed.
    • Factor VII levels returned to normal following recovery from sepsis.

    Conclusions:

    • Severe systemic sepsis can lead to a transient acquired factor VII deficiency.
    • Potential mechanisms include factor VII consumption or proteolytic degradation.
    • Recognition of this syndrome prevents misdiagnosis of congenital factor VII deficiency.