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Organizing diffuse alveolar damage associated with progressive systemic sclerosis

T E Muir1, H D Tazelaar, T V Colby

  • 1Division of Anatomic Pathology, Mayo Clinic Rochester, MN 55905, USA.

Mayo Clinic Proceedings
|July 1, 1997
PubMed
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Diffuse alveolar damage (DAD), a lung injury pattern, is now linked to progressive systemic sclerosis. This finding expands the known respiratory complications of this connective tissue disease.

Area of Science:

  • Pulmonology
  • Rheumatology
  • Pathology

Background:

  • Diffuse alveolar damage (DAD) is a recognized pattern of acute lung injury.
  • DAD is often associated with various connective tissue diseases.
  • Progressive systemic sclerosis is a systemic autoimmune disease affecting multiple organs.

Observation:

  • Two patients with progressive systemic sclerosis developed acute respiratory distress syndrome.
  • Histologic examination of lung biopsy specimens revealed DAD.
  • No other cause for DAD was identified in these patients.

Findings:

  • Diffuse alveolar damage (DAD) can occur in progressive systemic sclerosis.
  • This represents a previously unreported pleuropulmonary complication of the disease.

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Implications:

  • DAD should be considered in the differential diagnosis of acute lung injury in patients with progressive systemic sclerosis.
  • This finding may prompt further research into the mechanisms linking DAD and systemic sclerosis.
  • Clinical management of progressive systemic sclerosis may need to account for this potential respiratory complication.