Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomic reflexes and non-allergic rhinitis

A S Jones1

  • 1Department of Otolaryngology, University of Liverpool, Royal Liverpool University Hospital, United Kingdom.

Allergy
|January 1, 1997
PubMed
Summary

Non-eosinophilic non-allergic rhinitis (NENAR) may stem from autonomic nervous system imbalance. Topical fluticasone propionate treatment normalized nasal reflexes in NENAR patients, suggesting a targeted therapeutic approach.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A New Era of Morphological Investigations: Reviewing Methods for Comparative Anatomical Studies.

Integrative organismal biology (Oxford, England)·2023
Same author

Unusual Presentation of an Ovarian Cyst: Successful Laparoscopic Excision.

Journal of minimally invasive gynecology·2016
Same author

Accurate Identification of Anatomical Structures in a Normal Female Pelvis During Laparoscopic Surgery: A Survey Amongst Trainees and Consultants in Obstetrics and Gynaecology.

Journal of minimally invasive gynecology·2016
Same author

Micro-computed tomography: an alternative method for shark ageing.

Journal of fish biology·2012
Same author

Oranges causing Alimentary Obstruction.

British medical journal·2010
Same author

Validation of quantitative magnetic resonance for the determination of body composition of mice.

International journal of body composition research·2010

Area of Science:

  • Otolaryngology
  • Immunology
  • Autonomic Neuroscience

Background:

  • The nose conditions inhaled air for optimal pulmonary gas exchange through warming, humidification, and filtration.
  • These nasal functions are regulated by autonomic nervous system reflexes acting on nasal blood vessels and glands.
  • Perennial non-allergic rhinitis is classified into eosinophilic and non-eosinophilic types, with the latter potentially linked to autonomic dysfunction.

Purpose of the Study:

  • To investigate autonomic nervous system dysfunction in non-eosinophilic non-allergic rhinitis (NENAR).
  • To assess the impact of topical fluticasone propionate on nasal reflexes in NENAR patients.

Main Methods:

  • Studies involved assessing nasal patency responses to stimuli like axillary pressure, standing, isometric exercise, and cold pressor tests in NENAR patients and controls.
  • NENAR patients' nasal responses to these stimuli were compared with those of normal subjects.
  • The effect of topical fluticasone propionate versus placebo on nasal reflexes in NENAR patients was evaluated.

Main Results:

  • NENAR patients exhibited reduced nasal response to axillary pressure and abrogated nasal resistance decrease upon standing.
  • Isometric exercise and cold pressor tests, which minimally affect normal subjects, increased nasal resistance in NENAR patients.
  • Topical fluticasone propionate treatment normalized abnormal nasal reflexes in NENAR patients, while placebo showed no effect.
  • Systemic autonomic reflexes were unaffected by the treatment.

Conclusions:

  • Non-eosinophilic non-allergic rhinitis is characterized by abnormal nasal reflexes, suggesting a localized autonomic imbalance.
  • Topical fluticasone propionate effectively normalizes these nasal reflexes in NENAR, indicating its therapeutic potential for this condition.
  • The treatment's efficacy appears specific to nasal autonomic reflexes, not affecting systemic parameters.

Related Experiment Videos