Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morpholino antisense oligomers: design, preparation, and properties

J Summerton1, D Weller

  • 1ANTIVIRALS Inc., Corvallis, OR 97333, USA.

Antisense & Nucleic Acid Drug Development
|June 1, 1997
PubMed
Summary

Morpholino oligos offer a novel solution for antisense therapy challenges. These novel molecules demonstrate high specificity and predictable activity, overcoming previous limitations in treating intractable diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of commercial AI algorithms for the detection of fractures, effusions, and dislocations on real-world clinical data: A prospective registry study.

Radiography (London, England : 1995)·2025
Same author

Role of viral coinfection in post-pandemic invasive Group A streptococcal infections in adults, a nation-wide cohort study (iGASWISS).

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2025
Same author

Temporal trends and predictors of phthalate, phthalate replacement, and phenol biomarkers in the LIFECODES Fetal Growth Study.

Environment international·2023
Same author

A scoping review of risk-stratified bowel screening: current evidence, future directions.

Cancer causes & control : CCC·2022
Same author

The burden of COVID-19 infection in a rural Tamil Nadu community.

BMC infectious diseases·2021
Same author

Risk of missing colorectal cancer with a COVID-adapted diagnostic pathway using quantitative faecal immunochemical testing.

BJS open·2021

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Discovery

Background:

  • Antisense technology holds promise for treating intractable diseases.
  • Previous challenges include inadequate specificity, ineffective delivery, and unpredictable cellular activity.
  • Novel structural types are needed to advance antisense therapeutics.

Purpose of the Study:

  • To introduce Morpholino oligos as a novel antisense structural type.
  • To address key technical problems hindering antisense therapy progress.
  • To evaluate the design, preparation, and properties of Morpholino oligos.

Main Methods:

  • Overview of the design and preparation of Morpholino oligos.
  • Assessment of sequence specificity.
  • Evaluation of cellular activity and delivery.
  • Analysis of nuclease resistance and solubility.

Main Results:

  • Morpholino oligos effectively solve the sequence specificity problem.
  • They provide high and predictable activity within cells.
  • These oligos exhibit minimal nonantisense activity.
  • Morpholino oligos are nuclease-resistant, water-soluble, and designed for low production costs.

Conclusions:

  • Morpholino oligos represent a significant advancement in antisense technology.
  • They offer a viable solution to previously intractable challenges in antisense drug development.
  • This novel structural type has the potential to enable effective treatments for a broad range of diseases.

Related Experiment Videos