Related Experiment Videos
Long-term evaluation of a nonpulsatile mechanical circulatory support system
Y Wakisaka1, Y Taenaka, K Chikanari
1Department of Artificial Organs, National Cardiovascular Center Research Institute, Osaka, Japan.
Artificial Organs
|July 1, 1997
Summary
The improved National Cardiovascular Center (NCVC)-2 centrifugal pump (CP) demonstrates excellent antithrombogenicity and durability. Modifications enhanced washout flow and reduced flow separation, ensuring safe, prolonged use in cardiac support.
Area of Science:
- Biomedical Engineering
- Cardiovascular Devices
- Materials Science
Background:
- Centrifugal pumps (CPs) are crucial for cardiac support.
- Improving antithrombogenicity and durability of CPs is essential for long-term use.
- Previous designs relied on a central balancing hole (BH) for antithrombogenicity.
Purpose of the Study:
- To evaluate the enhanced antithrombogenicity, hemolytic properties, and mechanical durability of the modified National Cardiovascular Center (NCVC)-2 centrifugal pump.
- To assess the impact of widening the BH diameter and rounding thrust bearing edges on pump performance.
Main Methods:
- A long-term in vivo experiment was conducted using 3 goats.
- The NCVC-2 was implanted paracorporeally between the left atrium and aorta.
- The pump operated at approximately 2,800 rpm for extended durations (50, 200, and 367+ days).
Main Results:
- The NCVC-2 demonstrated excellent antithrombogenicity and acceptable hemolytic properties.
- Biomarkers (creatinine, BUN, GOT, GPT) remained stable, indicating no significant organ damage.
- Plasma free hemoglobin levels were consistently below 15 mg/dl, except in one late-stage case.
Conclusions:
- The modified NCVC-2 centrifugal pump exhibits excellent antithrombogenicity, suitable hemolytic properties, and adequate mechanical durability for prolonged cardiac support.
- Design modifications, including an enlarged BH and rounded bearing edges, effectively improved pump performance and safety.