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Related Experiment Videos

Development of the undulation pump total artificial heart

Y Abe1, T Chinzei, T Isoyama

  • 1Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.

Artificial Organs
|July 1, 1997
PubMed
Summary

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Researchers developed two implantable total artificial hearts (TAHs) using a novel undulation pump. The UPTAH 2 demonstrated successful implantation and short-term survival in a goat model, showing potential for future artificial heart applications.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Surgical Innovation

Background:

  • The development of compact and efficient blood pumps is crucial for creating implantable artificial heart systems.
  • Continuous flow displacement pumps offer potential advantages for artificial heart applications.

Purpose of the Study:

  • To develop and evaluate two types of implantable total artificial hearts (TAHs) utilizing an undulation pump design.
  • To assess the feasibility of implanting these devices in a relevant animal model.

Main Methods:

  • Design and fabrication of two undulation pump total artificial heart (UPTAH) models: UPTAH 1 and UPTAH 2.
  • Sizing and weight reduction of UPTAH devices for potential implantation.
  • In vivo testing of UPTAH 2 in an adult female goat model.

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Main Results:

  • UPTAH 1 and UPTAH 2 were successfully designed with reduced dimensions (75 mm diameter, 78-80 mm length) and weights (520-650 g).
  • UPTAH 2 was implanted in a 52.3 kg goat, achieving a good fit within the chest cavity.
  • The goat survived for 3 hours and 40 minutes post-implantation, indicating initial device function and tolerability.

Conclusions:

  • The undulation pump TAH (UPTAH) demonstrates potential as a practical implantable artificial heart.
  • The successful animal experiment validates the UPTAH's design and implantability for future research and development.