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Related Experiment Videos

Hemolysis test of disposable type vibrating flow pump

S Kobayashi1, S Nitta, T Yambe

  • 1Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.

Artificial Organs
|July 1, 1997
PubMed
Summary

The disposable vibrating flow pump (D-VFP) shows reduced hemolysis and minimal heat transfer compared to traditional VFP systems. This design is promising for extracorporeal circulation applications.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Hemodynamics

Background:

  • Vibrating flow pumps (VFP) offer compact design potential for extracorporeal circulation due to high-frequency oscillation and short stroke volume.
  • Traditional VFPs face challenges with hemolysis and heat transmission to blood.
  • A disposable variant (D-VFP) was developed to address these limitations.

Purpose of the Study:

  • To evaluate the hemolysis performance of the disposable vibrating flow pump (D-VFP) in a mock circulation setting.
  • To compare the D-VFP's hemolysis and heat transmission characteristics against a standard VFP and other common blood pumps.
  • To assess the D-VFP's suitability for extracorporeal circulation.

Main Methods:

  • Hemolysis tests were conducted using goat blood in a mock circulation loop.

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  • Plasma free hemoglobin levels were measured at 15-minute intervals for D-VFP, VFP, centrifugal pump, and roller pump.
  • Heat transmission was studied by monitoring fluid temperature changes in D-VFP and VFP systems.

    • Main Results:

    • The D-VFP exhibited significantly lower plasma free hemoglobin (16 mg/dl at 30 min) compared to the VFP (160 mg/dl at 30 min).
    • Centrifugal and roller pumps showed lower hemolysis (3 mg/dl and 9 mg/dl, respectively) than the D-VFP.
    • The D-VFP demonstrated negligible temperature increase in the fluid, unlike the VFP which showed a ~1°C rise.

    Conclusions:

    • The D-VFP design significantly reduces hemolysis compared to the conventional VFP.
    • Detaching the actuator minimizes heat transmission to the blood, a key advantage over the VFP.
    • The D-VFP shows potential as an improved pump for extracorporeal circulation, though further study on hemolysis is warranted.