Cardiovascular effects of 5-hydroxypropranolol (ORF 12592) in dogs

ORF 12592, the 5-hydroxy analog of propranolol, produced reductions in mean arterial pressure, heart rate, cardiac contractility and hind limb perfusion pressure in the anesthetized normotensive dog. Blood pressure and heart rate were also lowered in the carotid-sinus denervated dog. ORF 12592 blocked heart rate and blood pressure responses induced by isoproterenol. Similar results were observed with propranolol administration except for a transient decrease in blood pressure in the mormotensive dog. These results indicate that ORF 12592 possesses antihypertensive and beta-blocking properties in the anesthetized dog.