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[Practical problems associated with long-term opioid therapy]

R F Bell1

  • 1Anestesi og Intensivavdelingen, Smerteklinikken, Haukeland Sykehus, Bergen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|May 10, 1997
PubMed
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Long-term opioid therapy can cause physical dependency, leading to withdrawal symptoms upon abrupt cessation. Gradual dose reduction is crucial, even with alternative pain relief, to manage opioid dependence and avoid adverse reactions to medications like naloxone.

Area of Science:

  • Pharmacology
  • Pain Management
  • Clinical Medicine

Background:

  • Long-term opioid therapy frequently leads to physical dependence.
  • Abrupt cessation of opioids can precipitate acute abstinence symptoms.
  • Patients on chronic opioid treatment exhibit increased sensitivity to opioid antagonists such as naloxone.