Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age and the renin-aldosterone system

R H Noth, M N Lassman, S Y Tan

    Archives of Internal Medicine
    |October 1, 1977
    PubMed
    Summary

    Older adults exhibit lower plasma renin activity (PRA) than younger individuals, impacting low renin hypertension classification. Age significantly influences PRA levels and diagnostic criteria for low renin hypertension.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    What do we know About the Usefulness of <sup>18</sup>F-FDG PET-CT for the Management of Invasive Fungal Infection? An International Survey.

    Mycopathologia·2024
    Same author

    Clinical experience in the treatment of COVID-19 with monoclonal antibodies in solid organ transplant recipients.

    Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2023
    Same author

    Identification of Predictive Markers of Response to Immunomodulators in the Treatment of COVID-19 Patients.

    Clinical laboratory·2022
    Same author

    Searching for the best agent for antibiotic prophylaxis in patients undergoing transcatheter aortic valve implantation.

    The Journal of hospital infection·2018
    Same author

    Bronchoalveolar Lavage Fluid Cytology in Culture-Documented Invasive Pulmonary Aspergillosis in Patients with Hematologic Diseases: Analysis of 67 Episodes.

    Journal of clinical microbiology·2018
    Same author

    Biofilm production is not associated with poor clinical outcome in 485 patients with Staphylococcus aureus bacteraemia.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017

    Area of Science:

    • Gerontology
    • Cardiovascular Physiology
    • Endocrinology

    Background:

    • Plasma renin activity (PRA) is a key regulator of blood pressure.
    • Age is known to influence various physiological parameters, including hormonal regulation.

    Purpose of the Study:

    • To investigate the effect of age on plasma renin activity (PRA) in normotensive and hypertensive individuals.
    • To assess how age influences the classification of low renin hypertension (LRH).

    Main Methods:

    • Comparison of ambulatory PRA levels between young and older normotensive volunteers under unrestricted and low-sodium diets.
    • Analysis of renal function, aldosterone excretion, and plasma renin substrate in both age groups.
    • Evaluation of PRA classification using young versus older normotensives as controls.

    Main Results:

    • Older adults demonstrated significantly lower PRA compared to younger adults, irrespective of diet.
    • Renal function, aldosterone excretion, and plasma renin substrate were comparable between age groups.
    • Using young controls overestimated the incidence of LRH in older hypertensive patients.

    Conclusions:

    • Age substantially affects PRA levels and its classification, particularly in the context of hypertension.
    • The use of age-specific controls is crucial for accurate diagnosis and understanding of LRH.
    • Current diagnostic criteria may misclassify a significant proportion of older individuals due to age-related PRA changes.

    Related Experiment Videos