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Bioactive alkaloids from Illigera luzonensis

K S Chen1, Y C Wu, C M Teng

  • 1Ta-Jen Pharmaceutical Junior College, Taiwan, Republic of China.

Journal of Natural Products
|June 1, 1997
PubMed
Summary
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Researchers isolated nine aporphine and oxoaporphine compounds from Illigera luzonensis stems. Several compounds demonstrated significant antiplatelet aggregation and vasorelaxant activities, offering potential therapeutic applications.

Area of Science:

  • Phytochemistry
  • Pharmacology

Background:

  • Illigera luzonensis is a plant species known for its potential medicinal properties.
  • Aporphine and oxoaporphine alkaloids are classes of compounds with diverse biological activities.

Purpose of the Study:

  • To isolate and identify aporphine and oxoaporphine compounds from the stems of Illigera luzonensis.
  • To evaluate the antiplatelet aggregation and vasorelaxant activities of the isolated compounds.

Main Methods:

  • Phytochemical investigation guided by antiplatelet aggregation assays.
  • Isolation and structural elucidation of aporphine and oxoaporphine alkaloids.
  • In vitro testing of antiplatelet aggregation and vasorelaxant effects.

Main Results:

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  • Seven aporphines (actinodaphnine, N-methylactinodaphnine, launobine, dicentrine, O-methylbulbocapnine, hernovine, bulbocapnine) and two oxoaporphines (dicentrinone, liriodenine) were isolated.
  • N-methylactinodaphnine, dicentrine, O-methylbulbocapnine, liriodenine, and bulbocapnine were reported for the first time in this species.
  • Compounds actinodaphnine, N-methylactinodaphnine, launobine, dicentrine, O-methylbulbocapnine, and liriodenine exhibited significant antiplatelet aggregation activity.
  • Actinodaphnine and dicentrinone showed significant vasorelaxant activities.

    • Conclusions:

    • The stems of Illigera luzonensis are a rich source of bioactive aporphine and oxoaporphine alkaloids.
    • Several isolated compounds possess potent antiplatelet and vasorelaxant properties, warranting further investigation for pharmaceutical development.