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Related Experiment Videos

Development of a microcontroller-based automatic control system for the electrohydraulic total artificial heart

H C Kim1, P S Khanwilkar, G B Bearnson

  • 1Artificial Heart Research Laboratory, Seoul National University, Korea.

IEEE Transactions on Bio-Medical Engineering
|January 1, 1997
PubMed
Summary

A new automatic control system for the electrohydraulic total artificial heart (EHTAH) ensures physiological cardiac output and stability. This system demonstrated success in both in vitro and in vivo experiments for long-term artificial heart function.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Control Systems

Background:

  • The development of reliable artificial heart systems is crucial for treating end-stage heart failure.
  • Existing artificial hearts require sophisticated control systems to mimic physiological function and ensure patient safety.

Purpose of the Study:

  • To develop and evaluate an automatic physiological control system for the electrohydraulic total artificial heart (EHTAH).
  • To ensure the EHTAH system maintains physiological cardiac output, compensates for non-physiological conditions, and operates with stability and high power efficiency for long-term use.

Main Methods:

  • Development of an automatic control system for actively filled, alternately pumped ventricles.
  • In vitro testing using week-long continuous mock circulation tests.

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  • In vivo testing in acute and chronic animal experiments (calves).

    • Main Results:

    • The automatic control system successfully maintained physiological cardiac output in mock circulation tests.
    • The system demonstrated stability, reliability, and high power efficiency.
    • Chronic animal experiments showed successful operation for up to 21 days in automatic mode and 138 days in manual mode within a 159-day implant.

    Conclusions:

    • The developed automatic physiological control system is effective for long-term EHTAH use.
    • The system meets critical requirements for physiological response, adaptability, and operational efficiency.
    • Successful in vitro and in vivo results support the potential of this EHTAH control system for clinical application.