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Related Experiment Videos

Multivitamin supplementation and multiple births

M M Werler1, J D Cragan, C R Wasserman

  • 1Slone Epidemiology Unit, Boston University School of Public Health, Brookline, Massachusetts 02146, USA.

American Journal of Medical Genetics
|July 11, 1997
PubMed
Summary
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Maternal multivitamin use before and during early pregnancy may be linked to an increased risk of multiple births. However, data consistency is limited, and these findings do not impact current recommendations for neural tube defect prevention.

Area of Science:

  • Reproductive health
  • Epidemiology
  • Maternal-fetal medicine

Background:

  • Maternal multivitamin supplementation is known to reduce neural tube defect risks.
  • Emerging evidence suggests potential associations with other reproductive outcomes.
  • A Hungarian study reported a 40% increase in multiple births among periconceptional vitamin users.

Purpose of the Study:

  • To investigate the association between maternal multivitamin supplementation and multiple births.
  • To analyze supplementation timing in relation to conception.
  • To examine data from multiple birth defect studies.

Main Methods:

  • Retrospective data collection on multivitamin use from three large birth defect studies.
  • Categorization of supplementation timing: periconceptional, early, and later use.

Related Experiment Videos

  • Comparison of supplementation prevalence between mothers of multiple and singleton births.

    • Main Results:

    • Four out of five datasets indicated a 30-60% higher prevalence of periconceptional multivitamin supplementation among mothers of multiple births.
    • No significant pattern was observed for "early" or "later" multivitamin use.
    • Findings across datasets showed some inconsistencies.

    Conclusions:

    • Periconceptional multivitamin use may be tentatively associated with an increased prevalence of multiple births.
    • The observed association requires further investigation due to data limitations and inconsistencies.
    • Current recommendations for folate supplementation for neural tube defect prevention remain unchanged.