Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The coalescent process with selfing

M Nordborg1, P Donnelly

  • 1Department of Ecology and Evolution, University of Chicago, Illinois 60637-1573, USA. magnus@darwin.uchicago.edu

Genetics
|July 1, 1997
PubMed
Summary

Estimating the selfing rate from DNA data requires large sample sizes for accuracy. The method is sensitive to recent changes in the selfing rate, impacting genetic diversity studies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Using the coaches voice to improve the representation and experience of females in coaching: a Gaelic games perspective.

Frontiers in sports and active living·2024
Same author

A taste of space: Remote animal observations and discrete-choice models provide new insights into foraging and density dynamics for a large subarctic herbivore.

The Journal of animal ecology·2024
Same author

Intracranial aneurysms: The era of endovascular intervention in Australia.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2022
Same author

Evaluating the Impact of Cardiopulmonary Bypass Priming Fluids on Bleeding After Pediatric Cardiac Surgery: A Systematic Review and Meta-Analysis.

Journal of cardiothoracic and vascular anesthesia·2022
Same author

Correction to: Building on existing tools to improve chronic disease prevention and screening in public health: a cluster randomized trial.

BMC public health·2021
Same author

Building on existing tools to improve chronic disease prevention and screening in public health: a cluster randomized trial.

BMC public health·2021

Area of Science:

  • Population genetics
  • Molecular evolution
  • Bioinformatics

Background:

  • Estimating the selfing rate (s) is crucial for understanding plant mating systems and genetic diversity.
  • Previous methods, like Milligan's, have shown potential errors, necessitating refined approaches.

Purpose of the Study:

  • To develop a robust method for estimating the selfing rate using DNA sequence data.
  • To address and correct errors in existing estimation techniques.
  • To explore the influence of sample size and recent demographic changes on selfing rate estimation.

Main Methods:

  • Adaptation of the coalescent process to incorporate selfing.
  • Development of moment estimators for the selfing rate (s) and scaled mutation rate (θ).
  • Derivation of the likelihood surface for s and θ.

Main Results:

  • The adapted coalescent model provides a framework for selfing rate estimation.
  • Moment estimators and likelihood surfaces were derived for accurate parameter estimation.
  • Large sample sizes are essential for reliable estimation of the selfing rate.

Conclusions:

  • The proposed method offers a more accurate way to estimate selfing rates from DNA sequence data.
  • Selfing rate estimates are highly sensitive to recent fluctuations in the actual selfing rate.
  • Future research should focus on validating these estimators with diverse genomic datasets.

Related Experiment Videos