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Postnatal lead exposure and MK-801 sensitivity

D A Cory-Slechta1

  • 1Department of Neurobiology and Anatomy, University of Rochester, School of Medicine and Dentistry, NY 14642, USA.

Neurotoxicology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Postnatal lead (Pb) exposure in rats altered sensitivity to the NMDA receptor antagonist MK-801, with effects potentially reversible after exposure cessation. This highlights the critical role of developmental timing in Pb neurotoxicity.

Area of Science:

  • Neuroscience
  • Toxicology
  • Developmental Biology

Background:

  • Postweaning lead (Pb) exposure is linked to reduced sensitivity to the NMDA receptor antagonist MK-801.
  • The developmental period of NMDA receptor subunit maturation may be critical for Pb-induced neurochemical alterations.

Purpose of the Study:

  • To investigate if postnatal lead (Pb) exposure, during a key neurodevelopmental window, alters NMDA receptor complex function.
  • To compare the effects of postnatal Pb exposure with previously observed postweaning exposure effects.

Main Methods:

  • Rat pups were exposed to lead acetate (0, 100, or 350 ppm) from day 0 to 21 via lactating dams.
  • Operant drug discrimination procedures were used to assess MK-801 sensitivity in 9-month-old rats.
  • Substitutions with MK-801, phencyclidine (PCP), CPP, and NMDA were performed, followed by MK-801 re-testing after washout.

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Main Results:

  • Lead exposure enhanced MK-801 sensitivity before washout but attenuated it after washout, though effects were modest.
  • No significant Pb-related changes were observed in responses to PCP, CPP, or NMDA.
  • MK-801 and PCP fully substituted, while CPP and NMDA produced saline-like responding.

Conclusions:

  • Postnatal lead exposure can alter NMDA receptor sensitivity, suggesting effects may depend on ongoing exposure or be reversible.
  • The timing of lead exposure (postnatal vs. postweaning) significantly influences its impact on the NMDA receptor complex.
  • These findings emphasize the critical importance of the developmental stage during lead exposure for neurotoxic outcomes.