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Closed-loop drug infusion for control of heart-rate trajectory in pharmacological stress tests

C P Valcke1, H J Chizeck

  • 1Gensia, Inc., San Diego, CA 92121, USA. valcke@gensia.com

IEEE Transactions on Bio-Medical Engineering
|March 1, 1997
PubMed

Insights

A new system using arbutamine automates pharmacological stress testing for coronary artery disease (CAD) diagnosis. This closed-loop algorithm effectively controls heart rate, offering a safer and more efficient diagnostic method for cardiologists.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Coronary artery disease (CAD) diagnosis is crucial in cardiology.
  • Pharmacological stress testing is an emerging alternative to exercise stress testing (ETT).
  • A novel device-drug system for CAD diagnosis has been developed.

Purpose of the Study:

  • To develop and evaluate a closed-loop control algorithm for arbutamine infusion.
  • To create a pharmacodynamic (PD) model of heart rate (HR) response to arbutamine.
  • To assess the safety and efficacy of automated arbutamine delivery for stress testing.

Main Methods:

  • Development of a closed-loop control algorithm for intravenous arbutamine delivery.
  • Creation of a PD model to predict HR response to arbutamine.
  • Estimation of model parameters using clinical data from volunteers and patients.
  • Testing the algorithm via simulations, animal studies, and human clinical trials.

Main Results:

  • The control algorithm successfully managed HR increase along a predetermined trajectory.
  • Clinical trials demonstrated the algorithm's effectiveness in controlling arbutamine infusion.
  • Simulations, animal, and human trials validated the algorithm's performance.

Conclusions:

  • The developed algorithm enables precise control of arbutamine infusion for stress testing.
  • Automated drug delivery offers an efficient, effective, and safe method for pharmacological stress tests.
  • This system enhances the diagnostic capabilities for cardiologists managing CAD patients.

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