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Related Experiment Videos

Neutrophil emigration in the lungs

C M Doerschuk1, T Kumasaka, L Qin

  • 1Department of Environmental Health Harvard School of Public Health, Boston, MA 02115, USA.

Nihon Kyobu Shikkan Gakkai Zasshi
|December 1, 1996
PubMed
Summary

Neutrophil lung emigration uses multiple adhesion pathways, influenced by inflammatory mediators and cytokines. The specific pathway can shift during inflammation, particularly in recurrent pneumonia.

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Area of Science:

  • Immunology
  • Pulmonary Medicine
  • Cell Biology

Background:

  • Neutrophil emigration is crucial for lung inflammation.
  • Pulmonary microvasculature transmigration involves distinct adhesion pathways.
  • Stimulus-dependent cytokine production, like TNF-alpha, influences pathway selection.

Purpose of the Study:

  • To elucidate the mechanisms of neutrophil emigration in the lung.
  • To investigate the role of adhesion molecules (CD11/CD18, ICAM-1) in neutrophil transmigration.
  • To understand how inflammatory stimuli and resolution impact neutrophil emigration pathways.

Main Methods:

  • Analysis of neutrophil emigration pathways in response to various inflammatory stimuli.
  • Investigation of CD11/CD18 and ICAM-1 involvement in neutrophil transmigration.

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  • Comparative studies of acute versus recurrent pneumonia models.

    • Main Results:

    • Neutrophil emigration utilizes both ICAM-1 dependent and independent pathways.
    • Cytokines, such as TNF-alpha, regulate the choice between these pathways.
    • Recurrent pneumonia involves distinct adhesion mechanisms compared to acute inflammation, with a shift towards CD11/CD18-independent emigration.

    Conclusions:

    • Neutrophil lung emigration is a dynamic process involving multiple, stimulus- and context-dependent adhesion pathways.
    • The inflammatory milieu and resolution phase significantly alter the recruitment of adhesion molecules.
    • Further research is needed to identify ligands for CD11/CD18-independent and ICAM-1-independent adhesion pathways.