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Updated: Aug 15, 2026

Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
Primary structure and biological activity of hemoglobin-related hypothalamic peptides
1Institute of Biochemistry, NAS RA, Yerevan, Republic of Armenia.
Abstract:
Five individual fractions from bovine hypothalamic extract, displaying coronary constrictory activity, were isolated and sequenced. All of them belong to the hemorphin group of hemoglobin-derived peptides. These peptides bind calmodulin and activate calmodulin-dependent enzymes. The relationship of isolated peptides with other members of the hemorphin group is discussed. Several new fragments of hemoglobin alpha- and beta-chains with yet unidentified activity were obtained from the same source. Their amino acid sequences have considerable overlap with the known sequences of hemoglobin fragments isolated from other tissues.
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