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Related Experiment Videos

Serum enzymes in heat stroke: prognostic implication

A H Alzeer1, M A el-Hazmi, A S Warsy

  • 1Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Clinical Chemistry
|July 1, 1997
PubMed
Summary
This summary is machine-generated.

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Serum enzyme levels, including lactate dehydrogenase (LD), creatine kinase (CK), and aspartate aminotransferase (AST), can predict heat stroke (HS) survival. Higher enzyme levels indicate a poorer prognosis in HS patients.

Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Environmental Health

Background:

  • Heat stroke (HS) is a severe hyperthermia condition.
  • Elevated serum enzymes are observed in HS patients.

Purpose of the Study:

  • To evaluate serum enzymes as prognostic indicators in heat stroke patients.
  • To compare the prognostic value of serum enzymes with other clinical markers.

Main Methods:

  • Serum creatine kinase (CK), lactate dehydrogenase (LD), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were measured in 26 heat stroke victims and 10 controls.
  • Patients were categorized into quick recovery, critically ill, and deceased groups.
  • Receiver Operating Characteristic (ROC) curves were used to assess prognostic accuracy.

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Main Results:

  • Serum enzymes (CK, AST, ALT, LD) were significantly higher in HS victims compared to controls upon admission.
  • Non-survivors and critically ill patients had significantly higher admission serum enzyme levels than those with quick recovery.
  • Lactate dehydrogenase (LD) demonstrated the highest prognostic accuracy (AUC = 0.991), followed by CK and AST.
  • Serum enzyme levels were superior prognostic indicators compared to body temperature, anion gap, and serum potassium.

Conclusions:

  • Serum enzyme levels, particularly LD, CK, and AST, are valuable prognostic markers for heat stroke outcomes.
  • These biochemical markers can aid in identifying patients at higher risk of mortality or severe illness.