Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motor cortical reflex myoclonus: a case study with MEG

Y Terao1, Y Ugawa, R Hanajima

  • 1Department of Neurology, School of Medicine, University of Tokyo, Japan.

Electroencephalography and Clinical Neurophysiology
|June 1, 1997
PubMed
Summary

This study identifies a new type of cortical reflex myoclonus originating from motor cortex hyperexcitability, not sensory cortex. This condition, termed motor cortical reflex myoclonus, is stimulus-sensitive and can cause involuntary movements.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2018
Same author

Elevated Serum Pentosidine and Decreased Serum IGF-I Levels are Associated with Loss of Muscle Mass in Postmenopausal Women with Type 2 Diabetes Mellitus.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2015
Same author

Serum osteocalcin levels are inversely associated with abdominal aortic calcification in men with type 2 diabetes mellitus.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2013
Same author

Adiponectin in metabolic bone disease.

Current medicinal chemistry·2012
Same author

[Medical services directed at the children with neurodevelopmental disabilities--current knowledge and prospect].

No to hattatsu = Brain and development·2012
Same author

Undercarboxylated osteocalcin is positively associated with free testosterone in male patients with type 2 diabetes mellitus.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2012

Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Electrophysiology

Background:

  • Cortical reflex myoclonus is typically linked to sensory cortex hyperexcitability, often indicated by enhanced somatosensory evoked potentials (SEPs).
  • Understanding the precise cortical generators of myoclonus is crucial for diagnosis and treatment.

Observation:

  • A case study of a 25-year-old female with involuntary foot dorsiflexion, aggravated by intended movements.
  • Myoclonus was triggered by posterior tibial nerve stimulation, yet the somatosensory evoked potential (SEP) remained normal.
  • Spontaneous and pre-myoclonus spikes localized to the superior frontal gyrus, anterior to the paracentral sulcus.

Findings:

  • Paired-pulse magnetic stimulation revealed impaired inhibition in the leg motor cortex.

Related Experiment Videos

  • Sensory cortex excitability, assessed via paired SEP testing, was found to be normal.
  • These findings suggest motor cortex hyperexcitability as the primary driver of this myoclonus type.

    • Implications:

    • Proposes a new classification: motor cortical reflex myoclonus, originating from the motor cortex.
    • Highlights that motor cortex hyperexcitability alone can generate long loop reflexes.
    • This subtype is stimulus-sensitive, offering potential targets for therapeutic interventions.