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Granulocytic sarcoma with translocation (9;11)(p22;q23): two cases
1Department of Human Genetics, University of Newcastle upon Tyne, United Kingdom.
Cancer Genetics and Cytogenetics
|July 15, 1997
Summary
Granulocytic sarcomas with monocytic morphology, previously unreported, were found to have the t(9;11) abnormality. This finding aids in precise characterization and therapy selection for myeloid leukemia.
Area of Science:
- Hematology
- Oncology
- Cytogenetics
Background:
- Granulocytic sarcomas are localized myeloid leukemia cell deposits.
- Typically, they exhibit morphology of AML-M2 with t(8;21) or AML-M4 with inv(16).
Observation:
- This study reports two cases of granulocytic sarcoma with monocytic morphology.
- The malignant cells in these cases displayed the t(9;11)(p22;q23) chromosomal abnormality.
Findings:
- The t(9;11) abnormality, characteristic of AML-M5, has not been previously reported in granulocytic sarcoma.
- This cytogenetic finding is observed in up to 7% of childhood acute myeloid leukemia (AML).
Implications:
- Detection of t(9;11) in granulocytic sarcoma allows precise characterization of malignant cells.
- Cytogenetic analysis is crucial for selecting the most appropriate therapy for granulocytic sarcoma.
- This highlights the importance of cytogenetic evaluation in diagnosing and managing granulocytic sarcomas.