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Prenatally diagnosed neuroblastoma

S Acharya1, S Jayabose, S J Kogan

  • 1Division of Pediatric Hematology-Oncology, New York Medical College, Valhalla 10595, USA.

Cancer
|July 15, 1997
PubMed
Summary

Prenatally diagnosed neuroblastomas are often adrenal and cystic, with most infants having favorable stage and biologic features. These children have an excellent prognosis, with many cases potentially avoiding surgery through observation.

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Physical review letters·2022

Area of Science:

  • Pediatric Oncology
  • Developmental Biology
  • Cancer Genetics

Background:

  • Increasing incidence of prenatal neuroblastoma diagnoses necessitates comprehensive reviews.
  • This study reviews clinical and biologic features of 55 prenatally diagnosed neuroblastoma cases.
  • Focuses on understanding the characteristics and outcomes of this specific pediatric cancer subset.

Observation:

  • Prenatal diagnosis typically occurs after 32 weeks gestation.
  • Tumors are predominantly adrenal (93%), frequently cystic (44%).
  • Stage I (67%) and Stage IV-S (22%) disease are most common, with minimal Stage IV (5%).

Findings:

  • Favorable DNA index (>1) and absence of N-myc amplification in studied cases suggest better prognosis.
  • Liver is the most common site of metastasis (25%); bone involvement is absent.

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  • High survival rate (90%) observed, with surgery being curative in most cases.

    • Implications:

    • Prenatally diagnosed neuroblastomas often present with favorable features, leading to excellent prognoses.
    • Surgery is curative for most, but observation may allow spontaneous regression in select cases.
    • Highlights the importance of prenatal diagnosis for early detection and management of neuroblastoma.