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Related Experiment Videos

Volume reflex in diabetes

K P Patel1

  • 1Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198-4575, USA.

Cardiovascular Research
|April 1, 1997
PubMed
Summary
This summary is machine-generated.

The neural and humoral components of the volume reflex are altered in early diabetes mellitus. Further research is needed to understand the mechanisms behind these changes in diabetic kidney function.

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Area of Science:

  • Physiology
  • Nephrology
  • Endocrinology

Background:

  • The volume reflex is crucial for maintaining fluid balance.
  • Diabetes mellitus can significantly impact physiological regulatory mechanisms.
  • Understanding alterations in the volume reflex is key to managing diabetic complications.

Purpose of the Study:

  • To review and identify major abnormalities in the volume reflex during early diabetes.
  • To highlight gaps in current knowledge regarding the volume reflex in diabetes.
  • To explore the roles of neural and humoral components in diabetic volume reflex dysfunction.

Main Methods:

  • Examination of various components of the volume reflex.
  • Utilizing different models of diabetic rats.

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  • Review of existing literature on diabetes and the volume reflex.

    • Main Results:

    • The neural component of the volume reflex is altered in early diabetes.
    • Atrial natriuretic factor (ANF) actions within the kidney contribute to altered volume reflex.
    • Intrarenal factors may blunt renal excretory responses to acute volume expansion (VE) in diabetes.

    Conclusions:

    • Significant abnormalities exist in the volume reflex in diabetes.
    • Further investigation into the neural mechanisms of the volume reflex in diabetes is warranted.
    • Intrarenal factors and ANF play roles in the altered volume reflex observed in diabetic kidney function.