Related Experiment Videos
Phase II study of high-dose dexamethasone-based association in acute and delayed high-dose cisplatin-induced
I Sekine1, Y Nishiwaki, R Kakinuma
1Division of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa-city, Chiba, Japan.
British Journal of Cancer
|January 1, 1997
Abstract:
Thirty-three patients with lung cancer receiving 80 mg m(-2) cisplatin were treated with high-dose dexamethasone (32 mg m(-2) on days 1-3, 16 mg m(-2) on day 4 and 8 mg m(-2) on day 5) combined with granisetron on day 1 and metoclopramide on days 2-5. Twenty-eight (85%) patients had no nausea or vomiting on day 1, and 16 (48%) achieved total control on days 1-5 with acceptable toxicity. High-dose dexamethasone for cisplatin-induced delayed emesis should be further evaluated in a phase III trial.