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Patterns of meiotic variability of the (CAG)n repeat in the Huntington disease gene
G Lucotte1, N Gérard, A Aouizérate
1Center of Neurogenetics, CHU of Reims, France.
Genetic Counseling (Geneva, Switzerland)
|January 1, 1997
Abstract:
We have collected 76 parent-offspring (CAG)n values in 60 French Huntington's disease (HD) pedigrees. The analysis of intergenerational alterations in CAG repeat length shows that there is a correlation between repeat instability and parental repeat length. Paternally inherited cases are characterized by a preferential trend towards an increase in range of repeat sizes in offspring of HD patients.