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Effect of hyperglycemia on the intestinal elimination of p-nitrophenol in the rat
E Fischer1, A Rafiei, S Bojcsev
1Department of Pharmacology, University Medical School, Pécs, Hungary.
Abstract:
Effect of hyperglycemia on the intestinal elimination of p-nitrophenol has been investigated in rats. Hyperglycemia was produced by a continuous i.v. infusion of glucose, p-nitrophenol was used as a model compound for the investigation of intestinal metabolism and excretion of drugs. Intestinal conjugation of p-nitrophenol with glucuronic acid did not change significantly in hyperglycemic rats, however, formation of sulfoconjugate of p-nitrophenol was enhanced by hyperglycemia. Sum of metabolites (p-nitrophenol glucuronide and sulfate) appeared in the intestinal lumen in hyperglycemic rats was similar to the total luminal appearance of these metabolites of control rats.