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Pulmonary function abnormalities in patients with ulcerative colitis

P G Godet1, R Cowie, R C Woodman

  • 1Gastrointestinal Research Group, University of Calgary, Alberta, Canada.

The American Journal of Gastroenterology
|July 1, 1997
PubMed
Summary
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Pulmonary function abnormalities are common in ulcerative colitis (UC) patients, affecting over half of those studied. Smoking status did not predict these lung function issues in individuals with UC.

Area of Science:

  • Gastroenterology
  • Pulmonology
  • Clinical Medicine

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • Potential extraintestinal manifestations of UC, including pulmonary involvement, are increasingly recognized.
  • Pulmonary function abnormalities may be an underdiagnosed complication in UC patients.

Purpose of the Study:

  • To determine the frequency of pulmonary function abnormalities in a cohort of UC patients.
  • To compare UC patients with abnormal pulmonary function tests (PFTs) to those with normal PFTs regarding smoking history and pre-existing lung conditions.

Main Methods:

  • A consecutive sample of 100 ulcerative colitis patients was identified.
  • Sixty-six patients were eligible, and 55 (83% participation rate) completed the study.

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  • Pulmonary function tests (PFTs) were performed to assess lung function.

    • Main Results:

    • Pulmonary function abnormalities were detected in 30 (55%) of the participating UC subjects.
    • Abnormal PFT results could not be predicted by smoking status (current or past), family history of respiratory diseases, occupational history, or current medications.
    • No significant difference was found between UC subjects with abnormal PFTs and those with normal PFTs concerning smoking behavior or history of preexisting pulmonary disease.

    Conclusions:

    • Pulmonary function abnormalities are prevalent, found in over half of the studied ulcerative colitis patients.
    • Smoking status is not a reliable predictor of pulmonary function abnormalities in this UC cohort.
    • Further research is warranted to explore the underlying mechanisms and clinical implications of pulmonary involvement in ulcerative colitis.