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Elevated serum CA 125 concentration in patients with tuberculous peritonitis: a case-control study
H Simsek1, M C Savas, A Kadayifci
1Department of Internal Medicine, Hacettepe University Medical School, Ankara, Turkey.
The American Journal of Gastroenterology
|July 1, 1997
Summary
Elevated serum cancer antigen 125 (CA 125) levels are common in tuberculous peritonitis. Monitoring CA 125 normalization can aid in diagnosing and tracking treatment response for this condition.
Area of Science:
- Oncology
- Infectious Diseases
- Immunology
Background:
- Elevated serum cancer antigen 125 (CA 125) is associated with ovarian carcinoma and other conditions.
- Tuberculous peritonitis can mimic ovarian cancer, leading to misdiagnosis and unnecessary surgeries.
- Detailed studies on CA 125 levels in tuberculous peritonitis are limited.
Purpose of the Study:
- To investigate serum CA 125 levels in patients with tuberculous peritonitis.
- To assess the utility of CA 125 as a diagnostic and monitoring marker for tuberculous peritonitis.
Main Methods:
- Serum CA 125 levels were measured in 11 patients with tuberculous peritonitis.
- A control group of 20 healthy individuals was included for comparison.
- CA 125 levels were correlated with the response to antituberculous therapy.
Main Results:
- All patients with tuberculous peritonitis exhibited elevated serum CA 125 levels.
- The mean CA 125 level in the study group was 316.6 IU/ml, significantly higher than the control group's 13.8 IU/ml (p < 0.0001).
- Normalization of serum CA 125 levels closely correlated with successful antituberculous treatment.
Conclusions:
- Tuberculous peritonitis should be considered in the differential diagnosis of elevated CA 125.
- Accurate diagnosis can prevent unnecessary laparotomies for presumed ovarian cancer.
- Serum CA 125 serves as an effective marker for diagnosing and monitoring tuberculous peritonitis.