Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gastroenteric inflammation in children with ulcerative colitis

S S Kaufman1, J A Vanderhoof, R Young

  • 1Department of Surgery, Creighton University, Childrens Hospital, Omaha, Nebraska, USA.

The American Journal of Gastroenterology
|July 1, 1997
PubMed
Summary

Pediatric inflammatory bowel disease with upper gastrointestinal inflammation can be misdiagnosed. Gastroduodenal inflammation in children does not confirm Crohn's disease and may indicate ulcerative colitis, necessitating accurate diagnosis for effective treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expanded carrier screening for inherited genetic disease using exome and genome sequencing.

Journal of genetic counseling·2024
Same author

The Phenotypic Spectrum of New-onset IBD in Canadian Children of South Asian Ethnicity: A Prospective Multi-Centre Comparative Study.

Journal of Crohn's & colitis·2021
Same author

The history and development of breast implants.

Annals of the Royal College of Surgeons of England·2020
Same author

Phenotypic Variation in Paediatric Inflammatory Bowel Disease by Age: A Multicentre Prospective Inception Cohort Study of the Canadian Children IBD Network.

Journal of Crohn's & colitis·2019
Same author

The effect of pain on balancing behavior: Complexity analysis of mediolateral force trajectories.

Gait & posture·2019
Same author

Roles of ventral versus dorsal pathways in language production: An awake language mapping study.

Brain and language·2019

Area of Science:

  • Pediatric Gastroenterology
  • Inflammatory Bowel Disease (IBD) Research
  • Gastrointestinal Pathology

Background:

  • Distinguishing between Crohn's disease and ulcerative colitis in pediatric patients is crucial for appropriate management.
  • Gastroduodenal inflammation is often considered a hallmark of Crohn's disease in children.
  • This study investigates cases initially presumed to be Crohn's disease due to extensive inflammation.

Observation:

  • Five pediatric inflammatory bowel disease cases presented with both gastroduodenal and pancolonic inflammation.
  • All five patients initially received a presumptive diagnosis of Crohn's disease.
  • Chronic active gastritis and duodenitis were common findings, but noncaseating granulomas were absent.

Findings:

  • Subtotal proctocolectomy ultimately led to the diagnosis of ulcerative colitis in all five children.

Related Experiment Videos

  • Medical therapies were prolonged and ineffective before surgical intervention.
  • Upper gastrointestinal tract inflammation was observed in pediatric ulcerative colitis patients.

    • Implications:

    • Gastroduodenal inflammation alone is insufficient to diagnose Crohn's disease in children.
    • Accurate differentiation between Crohn's disease and ulcerative colitis is vital for timely surgical referral and optimal patient outcomes.
    • Further research into upper gastrointestinal tract involvement in pediatric ulcerative colitis is warranted.