Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimating post-synaptic potentials in tonically discharging human motoneurons

T S Miles1

  • 1Department of Physiology, The University of Adelaide, Australia. tmiles@physiol.adelaide.edu.au

Journal of Neuroscience Methods
|June 27, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Properties of synaptic noise in tonically active human motoneurons.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2010
Same author

Role of the primary motor and sensory cortex in precision grasping: a transcranial magnetic stimulation study.

The European journal of neuroscience·2008
Same author

Motor cortex excitability after thalamic infarction.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2005
Same author

Stretch reflexes in the human masticatory muscles: a brief review and a new functional role.

Human movement science·2004
Same author

Does induction of plastic change in motor cortex improve leg function after stroke?

Neurology·2003
Same author

Cortical excitability is not depressed in movement-modulated stretch response of human thumb flexor.

Experimental brain research·2001

Estimating post-synaptic potentials in human motoneurones using motor unit activity is challenging. Current methods, while useful, have limitations and require further validation against direct measurements.

Area of Science:

  • Neuroscience
  • Human Physiology
  • Motor Control

Background:

  • Single motor unit activity in human muscles is readily recordable.
  • Motor unit spike trains accurately reflect parent motoneurone activity.
  • This allows for estimation of stimulus-evoked post-synaptic potentials in motoneurones.

Purpose of the Study:

  • To review methods for estimating stimulus-evoked post-synaptic potentials in human motoneurones.
  • To highlight the assumptions and limitations of these techniques.
  • To discuss the need for validation against direct intracellular measurements.

Main Methods:

  • Review of existing literature on non-invasive techniques.
  • Analysis of methods relying on motor unit spike train manipulation.

Related Experiment Videos

  • Discussion of assumptions inherent in these estimation techniques.

    • Main Results:

    • Several methods exist to estimate post-synaptic potentials from motor unit activity.
    • These methods are based on manipulating spike trains across multiple trials.
    • No method has yet been directly validated against intracellular recordings.

    Conclusions:

    • Current techniques for estimating post-synaptic potentials have limitations.
    • Further research is needed to validate these indirect methods.
    • Direct intracellular measurements remain the gold standard for comparison.